Influence of Internal Structure of the Sorbents on Diazepam Sorption from Simulated Intestinal Fluid

The capacity of natural Na-montmorillonite and activated charcoal for sorption diazepam from simulated intestinal fluid (SIF) was studied. main characteristics the sorbents were determined. In order to characterize process influence pH, contact time ethanol presence in SIF analyzed. Adsorption isotherms diazepam-activated diazepam-natural systems Langmuir isotherm model provided a very good description sorption. Furthermore, pH-drift method used determine specific pH at zero point charge (pHzpc) sorbents. obtained results show that internal structure solutions are important Both surface positively charged below pHzpc so is higher this occur by van der Waals forces. lowers adsorption on both